000			03381cam a2200493 i 4500
001			18577358
003			OSt
005			20230503020011.0
008			150415s2016 nyua b 001 0 eng
010			_a 2015014810
020			_a9780071830935 (hardcover : alk. paper)
020			_a0071830936 (hardcover : alk. paper)
020			_a9789814670241 (pbk.)
020			_a9814670243 (pbk.)
035			_a(DNLM)101656208
040			_aDNLM/DLC _beng _cDLC _erda _dDLC
042			_apcc
050	0	0	_aRM301.4 _b.S52 2016
060	1	0	_aQV 38
082	0	0	_a615.7 _223
100			_aSHARGEL,Leon
245	1	0	_aApplied biopharmaceutics & pharmacokinetics / _ceditors, Leon Shargel, PhD, RPh, Applied Biopharmaceutics, LLC, Raleigh, North Carolina, Affiliate Professor, School of Pharmacy, Virginia Commonwealth University, Richmond, Virginia, Adjunct Associate Professor, School of Pharmacy, University of Maryland, Baltimore, Maryland, Andrew B.C. Yu, PhD, RPh, Registered Pharmacist, Gaithersburg, Maryland, formerly Associate Professor of Pharmaceutics, Albany College of Pharmacy, Albany, New York, formerly CDER, FDA, Silver Spring, Maryland.
246	3		_aApplied biopharmaceutics and pharmacokinetics
246	1	4	_aShargel & Yu's Applied biopharmaceutics and pharmacokinetics
250			_aSeventh edition.
264		1	_aNew York : _bMcGraw-Hill Education, _c[2016]
300			_axvii, 910 pages : _billustrations (some color) ; _c24 cm
336			_atext _2rdacontent
337			_aunmediated _2rdamedia
338			_avolume _2rdacarrier
504			_aIncludes bibliographical references and index.
505	0		_aIntroduction to biopharmaceutics and pharmacokinetics -- Mathematic fundamentals in pharmacokinetics -- Biostatistics -- One compartment open model : IV bolus injection -- Multicompartmental models : IV bolus injection -- Intravenous infusion -- Drug elimination and clearance -- Pharmacokinetics of oral absorption -- Multiple dosage regimens -- Nonlinear pharmacokinetics -- Physiologic drug distribution and protein binding -- Renal and hepatic elimination of drugs -- Pharmacogenetics and drug metabolism -- Physiologic factors related to drug absorption -- Biopharmaceutic considerations in drug product design -- Drug product performance, in vivo : bioavailability and bioequivalence -- Biopharmaceutic aspects of the active pharmaceutical ingredient and pharmaceutical equivalence -- Impact of biopharmaceutics on drug product quality and clinical efficacy -- Modified release drug products and drug devices -- Targeted drug delivery systems and biotechnology products -- Relationship between pharmacokinetic and pharmacodynamics -- Application of pharmacokinetics in clinical situations -- Application of pharmacokinetics in specific populations -- Dosage adjustment in renal and hepatic disease -- Empirical models, mechanistic models, statistical moment and noncompartmental analysis.
650		0	_aBiopharmaceutics.
650		0	_aPharmacokinetics.
650	1	2	_aBiopharmaceutics.
650	1	2	_aPharmacokinetics.
650	2	2	_aDrug Administration Routes.
650	2	2	_aModels, Chemical.
700	1		_aShargel, Leon, _d1941- , _eeditor.
700	1		_aYu, Andrew B. C., _d1945-, _eeditor.
906			_a7 _bvip _corignew _d1 _eecip _f20 _gy-gencatlg
942			_2nlm _cRES _01
999			_c12365 _d12365