Applied biopharmaceutics & pharmacokinetics / editors, Leon Shargel, PhD, RPh, Applied Biopharmaceutics, LLC, Raleigh, North Carolina, Affiliate Professor, School of Pharmacy, Virginia Commonwealth University, Richmond, Virginia, Adjunct Associate Professor, School of Pharmacy, University of Maryland, Baltimore, Maryland, Andrew B.C. Yu, PhD, RPh, Registered Pharmacist, Gaithersburg, Maryland, formerly Associate Professor of Pharmaceutics, Albany College of Pharmacy, Albany, New York, formerly CDER, FDA, Silver Spring, Maryland.

Includes bibliographical references and index.

Introduction to biopharmaceutics and pharmacokinetics -- Mathematic fundamentals in pharmacokinetics -- Biostatistics -- One compartment open model : IV bolus injection -- Multicompartmental models : IV bolus injection -- Intravenous infusion -- Drug elimination and clearance -- Pharmacokinetics of oral absorption -- Multiple dosage regimens -- Nonlinear pharmacokinetics -- Physiologic drug distribution and protein binding -- Renal and hepatic elimination of drugs -- Pharmacogenetics and drug metabolism -- Physiologic factors related to drug absorption -- Biopharmaceutic considerations in drug product design -- Drug product performance, in vivo : bioavailability and bioequivalence -- Biopharmaceutic aspects of the active pharmaceutical ingredient and pharmaceutical equivalence -- Impact of biopharmaceutics on drug product quality and clinical efficacy -- Modified release drug products and drug devices -- Targeted drug delivery systems and biotechnology products -- Relationship between pharmacokinetic and pharmacodynamics -- Application of pharmacokinetics in clinical situations -- Application of pharmacokinetics in specific populations -- Dosage adjustment in renal and hepatic disease -- Empirical models, mechanistic models, statistical moment and noncompartmental analysis.